DOACs vs warfarin / Synthesis
Synthesis & reporting
PRISMA flow
9,486
Records identified (4 databases)
1,084
Duplicates removed
8,402
Records screened
8,061
Excluded at title/abstract
341
Full-text assessed
127
Excluded (wrong comparator / design)
214
Studies included in synthesis
Auto-generated from live record counts · updates on re-run.
Meta-analysis · major bleeding (HR)
RE-LY
0.93 (0.81–1.07)
ROCKET-AF
1.04 (0.9–1.2)
ARISTOTLE
0.69 (0.6–0.8)
ENGAGE AF
0.8 (0.71–0.91)
Pooled (random)
0.86 (0.74–1.00)
0.5 favours DOACI²=71%1.4 favours warfarin →
Certainty of evidence · GRADE
| Major bleeding | Moderate ⊕⊕⊕○ | −1 inconsistency |
| Stroke / systemic embolism | High ⊕⊕⊕⊕ | no downgrade |
| All-cause mortality | Low ⊕⊕○○ | −2 imprecision |